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differential hematology management oncology workup syndrome primary treatment hemolytic rheumatology cirrhosis classification dermatology intravascular leukemia liver systemic alkaline alp biliary
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs Decreased RBC ... Disease • Marrow ... Thalassemia • RBC ... • RBC Metabolism ... #Algorithm #Causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Algorithm #Causes ... #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... • Extrinsic RBC ... • Intrinsic RBC ... #Algorithm #hematology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Algorithm Symptoms ... PBC if 2/3 criteria ... consistent with PBC ... #PBC #Primary ... #Algorithm #hepatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Unstable hemoglobin disorders ... Target Cell RBC ... #differential #diagnosis ... #hematology #microscopy
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Neutrophils - Low RBC ... • Small Bowel Disorder ... #Algorithm #Causes ... #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Algorithm Features ... hepatomegaly • Labs: anemia ... platelets, persistent WBC ... #Algorithm #hematology ... #WBC #Leukemoid
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... pylori test (GI symptoms ... changes), high MCV anemia ... ), HBsAg/anti-HBc ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... • Rheumatic disorders ... • Celiac disease ... Iron deficiency anemia ... #Algorithm #Causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
) - Summary PBC ... Pathophysiology ... intralobular bile ducts causes ... Signs and Symptoms ... #workup #hepatology
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