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rheumatology differential lupus oncology erythematosus sclerosis summary syndromes bee chronic classification cll comparison dermatology hemophagocytic hepatology hlh leukemia lymphocytic lymphohistiocytosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
accompanies other autoimmune ... erythematosus (SLE ... ) Signs / Symptoms ... #Pathophysiology ... #Diagnosis #Signs
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
conjunction with symptoms ... central nervous system ... an underlying autoimmune ... and treatment can ... #neurology #inflammatory
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... ), Sjogren's Syndrome ... : Lupus (SLE), Systemic ... Arthritis, Sjögren Syndrome ... #diagnosis #differential
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... skin thickening Signs ... and Symptoms: ... #diagnosis #signs ... #symptoms #testing
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
block • Sjogren syndrome ... Treatment: • ... #Summary #diagnosis ... #rheumatology # ... management
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
weakness, less systemic ... symptoms, and less ... anti-synthetase syndrome ... after 2 years of treatment ... #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... , PRES Pathophysiology ... #CNS #neurology ... #management #treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... • Lab values: WBC ... >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Demyelinating syndromes ... pain (20%) Renal disease ... #signs #symptoms ... #diagnosis #rheumatology
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Myositis, Comorbid autoimmune ... disorders (Systemic ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
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