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differential erythematosus management sle classification oncology criteria disease signs symptoms treatment workup activation agglutinin ana antibodies antinuclear arthritis autoantibodies autoimmune
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... ↑ LDH • Anti-RBC ... FOR a cause → Systematic ... #Anemia #diagnosis ... management #treatment #rheumatology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic ... Criteria CLINICAL ... anemia #Diagnosis ... #Rheumatology #
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Autoimmune Diseases: • Systemic ... lupus erythematosus ... hemolysis Nutritional ... #Hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... Clinical Domains ... pericarditis • Hematologic ... Thrombocytopenia, Autoimmune hemolysis ... #diagnosis #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... usually IgG) (e.g. lupus ... • Intrinsic RBC ... #hematology #anemia
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... Lupusreference #SLE #Systemic ... #differential #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Disease, PRES Pathophysiology ... permeability Diagnosis ... CNS #neurology #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
or Anti-NucIear Antibody ... likely it will be clinically ... lupus erythematosus ... ANA #patterns #rheumatology ... #diagnosis #differential
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Differential Diagnosis ... likelihood of negative clinical ... #CBC #hematology ... #pathophysiology
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