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diagnosis hematology algorithm causes management hepatology workup classification oncology rheumatology clinical dermatology nephrology treatment ultrasound abscess disorders hemolysis laboratory pathophysiology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential ... • Extrinsic RBC ... • Intrinsic RBC ... #Anemias #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Bleed • Hemolysis ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Differential #
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Morphology Microcytic RBC ... sometimes) Macrocytic RBC ... Bite Cell RBC: G6PD ... #Morphology #differential
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... Myelodysplastic syndrome ... uremic syndrome ... coagulopathy (DIC) #RBC ... key #diagnosis #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... Defects, Drugs, Liver ... 3) Internal (RBC ... Defects: Sickle cell anemia
Pathophysiology of Hemolytic Anemia - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects) -
Pathophysiology of Hemolytic ... Anemia - Defects ... in RBC internal ... - Defects in RBC ... #Anemia #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Neutrophils - Low RBC ... RBCs in Rouleaux ... Myelodysplastic Syndromes ... Cells, Normal WBCs
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... Anemia 1) DIAGNOSE ... AIHA • Anemia ... ↑ LDH • Anti-RBC ... • Blood smear: Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) - HELLP syndrome ... uremic syndrome ... • Intrinsic RBC ... Extravascular #Causes #differential
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... blood loss • Hemolytic ... Dilutional Effect • RBC
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