45 results
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis
 • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
- Differential Diagnosis ... Lemierre's syndrome ... Malignancy: - Hematologic ... ): Lupus, Rheumatoid ... #Differential #Diagnosis
Erythematous Rashes - THE ALGORITHMIC APPROACH

Characterized by diffuse redness of the skin due to
capillary congestion, erythematous
the Nikolsky sign ... staphylococcal scalded skin syndrome ... includes Kawasaki disease ... and toxic shock syndrome ... #Diagnosis #Dermatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Malar rash 40% - Fever ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
Behcet's Syndrome - Diagnosis
Diagnostic Criteria for Behget's Syndrome (International Study Group for Behget's Disease):
 • Recurrent,
Behcet's Syndrome ... - Diagnosis Diagnostic ... Abnormal pathergy test ... #disease #Diagnosis ... #criteria #rheumatology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Rheumatic fever ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #differential #diagnosis
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
(SLE) General: Fever ... Demyelinating syndromes ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
quadrant discomfort Signs ... associated autoimmune disease ... of autoimmune disease ... PBC if 2/3 criteria ... #Algorithm #hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... . lupus, CLL, lymphoma ... #hematology #anemia
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
Diagnostic Criteria ... Fever, temperature ... inflammatory disease ... #Diagnosis #Hematology ... #Dermatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Systemic lupus ... Liver function tests ... Histopathologic criteria ... #Diagnosis #Management ... #Hematology #Rheumatology