188 results
Sleep
Regulation of sleep is critical for life! Ever wonder why you can’t fall asleep while hungry
hungry or why anti-histamines ... #Sleep #anti-histamine
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Drug Induced Lupus ... cases, drug-dependent ... Discontinuation of causal ... Positive in 60-80% of cases
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... 5-10% - Anti- ... Diagnosis and Lupus ... : Drug-induced lupus ... SLE #Systemic #Lupus
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic lupus ... Farr assay) and lupus ... & drug-induced lupus ... SCLE, neonatal lupus ... Sjogren and neonatal lupus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... - Anti-histone ... Lupusreference #SLE #lupus
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... , Anti-Ro (SSA) ... and Anti-La (SSB ... glycoprotein I (ß2GP), Lupus ... (SSA), Anti-La
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Immunoglobulins (Anti-dsDNA ... , Anti-Sm, Anti-phospholipid ... sle #systemic #lupus
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... Anti-dsDNA (in 70% ... of cases) 2 ... Anti-histone (in ... seen in 30—70% of cases
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Churg Strauss) Anti-GBM ... Membranoproliferative • ↓C4: Lupus ... diagnosis #nephrology #causes
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Criteria for Systemic Lupus ... Acute cutaneous lupus ... IgG > 40 GPL or anti-ß2GPI ... antibodies domain: Anti-dsDNA ... antibody, Anti-Sm