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diagnosis hematology causes algorithm workup nutrition acidosis hemolysis lactate macrocytic mcv rheumatology vitaminb12 atlas cobalamin elevation erythematosus extravascular folate folicacid
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... crisis • Severe B12 ... deficiency • Mechanical ... hemolytic anemia ... #schistocytes #differential
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... • Bleeding • Hemolysis ... (>100 fL) • B12 ... #MCV #Classification ... #Differential #
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... -100): • Non-hemolytic ... , CKD • Hemolytic ... , B12 deficiency ... MCV #Algorithm #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential ... DAT (-) → G6PD Deficiency ... → Sickle Cell anemia ... #Anemia #Differential
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... • Vitamin E - Haemolytic ... gestation • Vitamin B12 ... #Vitamins #Deficiency ... #differential #
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Macrocytic RBC: Vitamin B12 ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... RBC #Morphology #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Defects • G6PD deficiency ... • PK deficiency ... anemia • ... Extravascular #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... • Early Iron Deficiency ... #Differential #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... anemia): ... G6PD deficiency) ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis ... consumption • Vitamin B12
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