121 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... consumption • Vitamin B12 ... deficiency Infections ... Differential #Diagnosis #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Inflammation, Chronic Infection ... (>100 fL) • B12 ... Algorithm #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
- Low Serum B12 ... • Pancreatic Disease ... Myelodysplastic Syndromes ... • Liver Disease ... Algorithm #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Myelofibrosis Infectious ... disorders • Celiac disease ... Non malignant hematologic ... effect following treatment ... Iron deficiency anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach to Anemia ... Macroangiopathic, Infections ... Folate deficiency, B12 ... Non-megaloblastic: Liver disease ... Differential #Diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome
Treatments for Sickle Cell disease

#Sicklecell #sicklecelldisease #sicklecellanemia, #sicklecells #sickle #hematology #anemia #clinical #pediatrics #FOAM #FOAMed
Treatments for Sickle ... Cell disease ... sicklecells #sickle #hematology ... #anemia #clinical
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
chronic kidney disease ... Megaloblastic: Vitamin B12 ... Alcohol use, Liver disease ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
loss), Vitamin B12 ... Chronic kidney disease ... (e.g. cancer, infection ... G6PD deficiency), Infections ... Production #Index #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... Non-lmmune: • HELLP Syndrome ... Vasculitis • Infection ... Algorithm #Causes #Hematology