62 results
diagnosis differential management anemia algorithm hemolytic oncology thrombocytopenia syndrome classification hemolysis hemophagocytic hlh intravascular lymphohistiocytosis mcv aflp aiha cirrhosis coagulation
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Differential Diagnosis Table ... Agglutinin Disease ... MatthewHoMD #Autoimmune ... #hematology
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Warm vs Cold Autoimmune ... Spherocytes • Treatment ... transient hemolysis • Treatment ... #Anemia #hematology ... #diagnosis #comparison
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • B12 ... methotrexate) • Drugs Autoimmune ... Diagnosis #Algorithm #Causes ... #Hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
DAT Results in Autoimmune ... , C3d ( +/- ) Cold ... agglutinin disease ... ) Paroxysmal cold ... #Hemolysis #hematology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
decades of life Causes ... Autoimmune diseases ... fever, fatigue, Nausea ... Urticaria #diagnosis #rheumatology ... #comparison #table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... (AIHA)"Cold" (usually ... (e.g. primary cold ... Extravascular #Causes ... differential #diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... Inflammatory and Autoimmune ... Diseases: • Systemic ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Advanced Liver Disease ... - Malignancy, Autoimmune ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... esp if severe disease ... azathioprine Cold ... #management #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... disorders • Celiac disease ... effect following treatment ... Diagnosis #Algorithm #Causes ... #Hematology
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