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diagnosis management differential lupus syndrome dermatology algorithm classification erythematosus oncology systemic vasculitis comparison workup anemia antinuclear autoantibodies joint msk pain
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
; common in SLE, ... RA Anti-dsDNA - SLE ... - Drug-induced SLE ... #diagnosis #table ... #rheumatology #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... Cryoglobulinemia (MIXED) • ANCA ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology #
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... • Specific for SLE ... Treatment: • ... Ann Marie Kumfer ... Summary #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Workup: - ANA ... Positive in 60-80% of cases ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... life-threatening • Treatment ... Evolution: Chronic disease ... #comparison #table ... #rheumatology #
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Pancreatic Disease ... and Folate Deficiency ... • Liver Disease ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
PT, aPTT(liver disease ... function test, ANA ... (e.g., SLE), anti-phospholipid ... bypass), LFT (liver disease ... #Workup #hematology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Nodosa (PAN), ANCA ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... Highly specific for SLE ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology ... #table #ANA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... connective tissue disease ... antibodies #diagnosis #rheumatology ... #diseases
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