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diagnosis management differential erythematosus syndrome systemic druginduced myelodysplastic vasculitis activation anemia aortitis aplastic cerebritis cns comparison cryoglobulinemia cryoglobulins dil framework
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... Maheswaranathan, MD ... Erythematosus #SLE ... CNS #neurology #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... life-threatening • Treatment ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... constitutional symptoms • Treatment ... Discontinuation of causal ... life-threatening • Treatment ... #table #rheumatology
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... 0.5-0.7 g/g by 12 ... months Classification ... Nephritis #Management #treatment ... #management #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... only curative treatment ... Myelodysplastic #Syndrome #MDS ... Diagnosis #Management #treatment ... #hematology #oncology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Nutritional: B12 ... infection (TB), MDS ... - Autoimmune: SLE ... Diagnosis #Framework #hematology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
(RA), Systemic lupus ... erythematosus (SLE ... (SPA) • Other Causes ... Maheswaranathan, MD ... Differential #Diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... Erythematosus #Diagnosis #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... Hypocellular/Hypoplastic MDS ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... (e.g. systemic lupus ... diagnosis #types #classification ... #rheumatology #
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