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diagnosis rheumatology causes management oncology signs algorithm erythematosus hemolysis sle systemic thrombocytopenia classification disease syndromes thrombocytosis agglutinin ana antibodies antibody
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... syndrome (ST-HUS ... crisis • Severe B12 ... anemia" • HELLP ... #diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Inflammatory and Autoimmune ... Diseases: • Systemic lupus ... #Diagnosis #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... • Blood smear: Differential ... #Hemolytic #Anemia ... diagnosis #management #treatment ... #rheumatology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... , CKD • Hemolytic ... - Extrinsic: Autoimmune ... Folate deficiency, B12 ... #Diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... methotrexate) • Drugs Autoimmune ... Non-lmmune: • HELLP Syndrome ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Macrocytic RBC: Vitamin B12 ... hemolytic anemia ... hemolytic anemia ... RBC #Morphology #differential ... #diagnosis #hematology
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
• Vitamin E - Haemolytic ... Wernicke-Korsakoff syndrome ... gestation • Vitamin B12 ... Vitamins #Deficiency #differential ... diagnosis #signs #symptoms
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
loss), Vitamin B12 ... : Autoimmune, Microangiopathic ... hemolytic anemia ... Production #Index #hematology ... #anemia #differential
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
PRODUCTION • Vitamin B12 ... Destruction: Zieve's syndrome ... , Autoimmune hemolytic ... anemia, Hemolysis ... #Diagnosis #Hepatology
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