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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... #SLE #hematology ... #rheumatology # ... differential #diagnosis #causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... Positive in 60-80% of cases ... lupus #Systemic #Erythematosus ... #Summary #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Causes of Splenomegaly ... Systemic Lupus Erythematosus ... Spherocytosis • Acquired causes ... Diagnosis #Algorithm #Causes ... #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... autoantibodies that will cause ... Systemic #Lupus #Erythematosus ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Systemic Lupus Erythematosus ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... Summary #diagnosis #rheumatology ... #management
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Systemic Lupus Erythematosus ... #differential #hematology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Systemic lupus erythematosus ... (SPA) • Other Causes ... common bacterial causes ... Mycobacterial Causes ... Differential #Diagnosis #rheumatology
Tinea Versicolor (Pityriasis versicolor) 
NOT a dermatophyte infection 
Caused by saprophytic, lipid-dependent yeasts 
Clinical 
 •
dermatophyte infection Caused ... hyperpigmented or erythematous ... meatballs appearance Management ... SkinRash #Diagnosis #Management
Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Evaluation and Management ... of Sickle Cell Crises ... Manifestations and Management ... #Diagnosis #Management ... #Hematology #SickleCell