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management differential oncology syndrome algorithm table causes disease workup anemia anticoagulation hasbled reactions risk activetb afib aplastic bleed blood chads2
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
- Differential Diagnosis ... B-symptoms, bruising/bleeding ... predominant immature cells ... #Algorithm #hematology ... #WBC #Leukemoid
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... - History of Bleeding ... Reed-Sternberg Cells ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Symptoms: • Malaise, bleeding ... fever, joint pain, bleeding ... night sweats, bleeding ... #Hematology #Oncology ... #Diagnosis
Stroke and bleeding risk stratification with the CHADS2-VASc and HAS-BLED schemas #Diagnosis #Hematology #CHADS2 #CHADS2VASc #HASBLED #Comparison
Stroke and bleeding ... HAS-BLED schemas #Diagnosis ... #Hematology #CHADS2 ... CHADS2VASc #HASBLED #Comparison
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 Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Chronic Myelogenous Leukemia ... effect following treatment ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
neutropenia • Mucosal bleeding ... Symptomatic anemia Diagnosis ... to MDS or acute leukemia ... #management #treatment ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... transformation to acute leukemia ... only curative treatment ... #Management #treatment ... #hematology #oncology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
- Differential Diagnosis ... Chronic myelogenous leukemia ... pancytopenia, blast cells ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
common inherited bleeding ... • Prolonged bleeding ... factor VIII) Treatment ... VonWillebrand #Disease #Diagnosis ... #Hematology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients) Important notes: • No
Bleeding risk calculators ... validated for VTE treatment ... with very high bleeding ... Anticoagulation #Factors #Hematology ... #Diagnosis
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