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diagnosis management differential rheumatology algorithm syndrome cardiology oncology clinical radiologyassistant causes dermatology hepatology cxr table classification ctchest pathophysiology pharmacology medications
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Symptoms: • Malaise, bleeding ... extramedullary disease ... fever, joint pain, bleeding ... • Significant bleeding ... #Hematology #Oncology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Features of hematologic ... B-symptoms, bruising/bleeding ... predominant immature cells ... Diagnosis #Algorithm #hematology ... #WBC #Leukemoid
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Chronic Myelogenous Leukemia ... disorders • Celiac disease ... Non malignant hematologic ... effect following treatment ... states • Non-hematologic
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Neoplastic: - Leukemia ... - History of Bleeding ... Lymphoblastic Leukemia ... Reed-Sternberg Cells ... Algorithm #Causes #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
Von Willebrand Disease ... common inherited bleeding ... factor VIII) Treatment ... VonWillebrand #Disease ... #Diagnosis #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
anemia, Liver diseases ... , Liver diseases ... , Bleeding gastric ... PD deficiency, Pulmonary ... #differential #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
neutropenia • Mucosal bleeding ... megaloblastic anemia Treatment ... to MDS or acute leukemia ... diagnosis #management #treatment ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Skin: - CLL cells ... or basket cells ... can indicate disease ... microglobulin Treatment ... workup #oncology #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
involved) • No leukemic ... type (B cell, T cells ... Hepatosplenomegaly, cytopenias(bleeding ... Lymphomas • Other hematologic ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... • Severe Liver Disease ... Treatment: ... diagnosis #causes #treatment ... #management #hematology
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