14 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Normal PT (INR) - Bleeding ... PT (INR) - No Bleeding ... #Differential #Diagnosis ... Algorithm #Causes #Hematology ... #coagulation #disorders
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... - Differential Diagnosis ... #Bleeding #Bruising ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
common inherited bleeding ... • Prolonged bleeding ... factor VIII) Treatment ... VonWillebrand #Disease #Diagnosis ... #Hematology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
lead to severe bleeding ... hemorrhage, while under-coagulation ... #pharmacology #treatment ... decisionaid #cardiology #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... Treatment: ... #diagnosis #causes ... #treatment #management ... #hematology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
Bleeding risk calculators ... validated for VTE treatment ... with very high bleeding ... Anticoagulation #Factors #Hematology ... #Diagnosis
Thromboelastogram Interpretation
Reaction Time (R Value):
 - Time till initiation of fibrin clot
 - Treatment: FFP, protamine
K
fibrin clot - Treatment ... interaction - Treatment ... after MA/MCF - Treatment ... Thromboelastography #diagnosis ... #coagulation #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
neutropenia • Mucosal bleeding ... Symptomatic anemia Diagnosis ... megaloblastic anemia Treatment ... #management #treatment ... #hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Hemophilia - Diagnosis ... Classify severity Treatment ... by a hemophilia treatment ... #Management #treatment ... #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
purpura to mucosal bleeding ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology