23 results
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia

Fanconi Anemia
Acquired Aplastic Anemia
Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... Acquired Aplastic ... Telemore Biology Disorders ... BoneMarrow #Failure #Aplastic ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... Deficiency • Aplastic ... of Chronic Disease ... • RBC Membrane Disorder ... Algorithm #Causes #Hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... neutropenia • Mucosal bleeding ... • Symptomatic anemia ... Medicine @SCVMCMed #Aplastic ... management #treatment #hematology
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Anemia - Underproduction ... - Anemia of chronic ... of chronic kidney ... Probable bone marrow disorder ... Underproduction #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Polycythemia Vera • Chronic ... : • Acute or Chronic ... • Rheumatic disorders ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... of Chronic Disease ... 80-100 fL) • Bleeding ... Algorithm #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... RA, SLE, PRV, Chronic ... #Normocytic #Anemia ... Algorithm #Causes #Hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... T-cell - CD7, CD3 Chronic ... • Myloid Disorders ... Pelger-Huet, Macrocytic anemia ... #hematology #Markers
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... mutations) • Immune Aplastic ... ecchymoses, mucosal bleeding ... #hematology #diagnosis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
of chronic inflammation ... deficiency (including chronic ... deficiencies: Chronic ... marrow failure: Aplastic ... Production #Index #hematology