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Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Management Summary Clinical ... Signs: • hyperCalcemia ... 28% (bone demineralization ... • Anemia 78% (bone ... macrocytic • Bone
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
Pathogenesis and clinical ... mechanical loading => Bone ... strain => Bone ... pathophysiology #symptoms #signs
Osteoarthritis (OA): Clinical findings • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
Osteoarthritis (OA): Clinical ... in subchondral bone ... architecture -> Palpable bony ... contact between bony ... pathophysiology #diagnosis #signs
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
Pathogenesis and clinical ... 3: Necrosis of bone ... destroying thin bony ... inner cortical bone ... pathophysiology #signs
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
in GBA1 gene Clinical ... Osteonecrosis, bone ... Disease #Diagnosis #Signs
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Pathogenesis and Clinical ... -> Reduced Bone ... Formation, Increased Bone ... pathophysiology #signs
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
Pathogenesis and Clinical ... to the scaphoid bone ... vessels that perfuse bone ... hypolucency "Crescent sign ... pathophysiology #diagnosis #signs
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
Pathogenesis and clinical ... tear a portion of bone ... onto lateral hip Signs ... pathophysiology #signs
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
Pathogenesis, clinical ... and underlying bone ... joint capsule or bone ... Dislocation #Diagnosis #signs
Paget’s Disease: Pathogenesis and Clinical Findings • Incr serum CTx - marker of bone resorption •
Pathogenesis and Clinical ... CTx - marker of bone ... resorption • Lytic bone ... ALP - marker of bone ... pathophysiology #diagnosis #signs
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