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Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... Levels - C3, C4 • SLE ... • Infection eg SBE ... ThePeanutKidney #Complement
Lupus - Role of complement and anti-dsDNA for the detection of flares Complement - ↓ Decreased Anti-dsDNA -
Lupus - Role of complement ... detection of flares Complement ... Increased #Lupus #SLE ... biomarkers #antidsdna #complement
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Erythematosus (SLE ... HLA-DR3 genes, complement ... self-antigens, activating complement ... Erythematosus #SLE
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... 80% - Low complement ... management of SLE ... Lupusreference #SLE
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... Vasculitis - Normal Complement
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... 90% - Low complement ... 80% - Low complement ... management of SLE ... druginduced #lupus #sle
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... anticoagulant - Low complement ... #Rheumatology #SLE
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
autoimmune like SLE ... It is complement ... with Eculizumab (complement
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
anticoagulant • Complement ... Classification #Criteria #SLE
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
is due to TTP, compliment-mediated ... catastrophic APS, SRC, SLE
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