3717 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Manifestations • Immune Complex ... Myopathy (Also caused ... Complications #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
antigen-antibody complexes ... self-antigens are the cause ... antigens are the cause ... Allergy #Immunology #pathophysiology
Causes of B12 deficiency. 

This great diagram shows normal absorption and outlines most possible causes. At
Causes of B12 deficiency ... most possible causes ... The IF-Cbl complex ... #Differential #Causes ... #Diagnosis #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... immunofluorescence Immune Complex
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... inflammation (complex ... Manifestations #pathophysiology
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
antigen-antibody complexes ... Viral replication causes ... PolyarteritisNodosa #Pathophysiology
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
multicomponent complexes ... Initiation phase caused ... models #hematology #pathophysiology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... antibiody -> Immune Complex ... > Incr Immune Complex ... Vasculitis #HUV #Pathophysiology
Tachycardia - Differential Diagnosis Table - Wide vs Narrow, Regular vs Irregular

Regular Rhythm - Narrow Complex
Rhythm - Narrow Complex ... Rhythm - Wide Complex ... whether AF is cause ... Tx: Underlying cause ... Narrow #Irregular #causes
Causes of Tachycardia - Differential Diagnosis Algorithm
Narrow Complex - Regular:
 • Sinus tachycardia
 • Atrial flutter
Causes of Tachycardia ... Algorithm Narrow Complex ... tachycardia Narrow Complex ... conduction Wide-Complex ... Diagnosis #Algorithm #Causes