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Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Table Warm AIHA ... (7-8%) DAT-negative ... #Autoimmune #Hemolytic
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... 1) DIAGNOSE AIHA ... haptoglobin ↑ indirect ... autoantibodies: positive direct ... screening 3) TREAT AIHA
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... - Warm vs Cold AIHA ... IgG mediated - DAT ... IgM mediated - DAT ... #Autoimmune #Hemolytic
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Differential Diagnosis Algorithm ... • ↑ LDH • ↑ Indirect ... Anemias (AIHAs) ... Differential #Diagnosis #Algorithm
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
in Autoimmune Hemolysis ... DAT Negative Hemolysis ... ), C3d ( - ) WAIHA ... BrighamChiefs #direct ... #Autoimmune #Hemolysis
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Immune mediated hemolysis ... Microangiopathic hemolytic ... Differential #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... Differential #Diagnosis #Algorithm
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Anemia (AIHA) ... #Autoimmune #Hemolytic ... #Anemia #AIHA # ... #Differential #Algorithm
Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... think of immune hemolysis ... , hemolytic transfusion ... #Classification ... Diagnosis #Causes #Algorithm
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
and Management Algorithm ... function panel, Direct ... LDH • ↑ Total/indirect ... aPTT normal • DAT ... Diagnosis #Management #Algorithm
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