13 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... infections • Tissue damage ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Causes of Thrombocytosis ... Infectious: • Acute ... disease Tissue Damage ... effect following treatment ... #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... and endothelial damage ... and endothelial damage ... Imaging: CXR- pulmonary ... diagnosis #management #hematology
A quick infographic on the importance of sun protection and the various results of sun damage
#wavelengths #causes ... #diagnosis #dermatology ... Acute effects of ... occupational disease evaluation ... Mechanisms and treatments
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
B-LNH), solid cancers ... Drugs, Unknown cause ... Treatment: • ... inhibitors under evaluation ... #summary #rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - ACS, AKI, acute ... signs of end organ damage ... • Treatment: ... diagnosis #management #hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
normal in mild cases ... - Acute Bleeding ... by a hemophilia treatment ... center. ... #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
without other cause ... : 33% • Treatment ... At least 3 of (Acute ... , and CXR with pulmonary ... Transfusion #Reactions #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
malignancy (Especially acute ... Fibrinolysis → End organ damage ... Treat primary cause ... #treatment #management ... #hematology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
vessels involved/damaged ... of the steroid treatment ... Treatment of GCA ... Start steroids if concern ... them, but urgent rheumatology