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differential algorithm causes rheumatology management workup bleeding disorders hepatology iron laboratory nephrology testing thrombocytosis alkaline alp approach arthritis atlas b12
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... disorders • Celiac ... disease Tissue ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... with anemia, diagnose ... tests Test for celiac ... disease with serology ... #Evaluation #workup
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... , deficiency anemia ... Vasculitides, IBD, Celiac ... disease, Kawasaki ... #Differential #Diagnosis
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... Malignant tumors, Acute ... , Liver diseases ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... Diagnosis Algorithm ... - Structural: Celiac ... disease, Tropical ... #ferritin #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Diagnostic Framework ... chronic kidney disease ... , Acute blood loss ... #differential #diagnosis ... #causes #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g. celiac ... disease, CF, IBD ... catastrophes, Acute ... table #comparison #diagnosis ... #hematology #deficiency
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Blood Loss • Acute ... • B12/Folate Deficiency ... Disease • Marrow ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Chronic kidney disease ... Index > 3: • Acute ... , G6PD deficiency ... Production #Index #hematology ... #diagnosis #calculation
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Nutritional: DiabetesB12 deficiency ... , Uremia/ESRD, Hypothyroidism ... , Acute intermittent ... #differential #diagnosis ... #causes #neurology
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