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differential causes algorithm oncology syndrome disease thrombocytosis classification hemeonc hemophagocytic hlh lupus lymphohistiocytosis sle summary aosd aplastic cll dermatology erythematosus
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Reactive: • Anemia ... Non-infectious (malignancy, rheumatologic ... Myelofibrosis • Chronic ... Myeloid Leukemia ... causes #Platelets #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Treatment: • Consider ... to MDS or acute leukemia ... #diagnosis #management ... #treatment #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential Diagnosis ... malignancies • Anemia ... myeloid leukemia ... (CML) - Dr. ... #Causes #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Diagnostic Framework ... of chronic inflammation ... of chronic kidney ... #differential #diagnosis ... #causes #hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
- Differential Diagnosis ... hepatomegaly • Labs: anemia ... , ↑ MCV, ↑/↓ platelets ... #Algorithm #hematology ... #WBC #Leukemoid
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... - Differential Diagnosis ... #MCV #Classification ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... RBCs on Smear • Chronic ... • Anemia of Chronic ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... transformation to acute leukemia ... only curative treatment ... #Management #treatment ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... (Chronic Myeloid ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
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