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diagnosis management differential hivaids opportunistic pharmacology idsa algorithm causes oncology syndrome rheumatology chronic dermatology disease infectiousdiseases thrombocytopenia thrombocytosis workup aplastic
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
immunosuppression (eg ... allogeneic HSCT, SOT ... HSCT; sn lower in SOT ... this morphology Treatment ... Diagnosis #Management #treatment
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelofibrosis Infectious ... Non malignant hematologic ... effect following treatment ... states • Non-hematologic ... Iron deficiency anemia
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g ... . cancer, infection ... Marrow suppression (e.g ... G6PD deficiency), Infections ... Production #Index #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... : • Recurrent infections ... Treatment: • Consider ... diagnosis #management #treatment ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... differential #diagnosis #hematology ... #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... hemolysis, deficiency anemia ... Rebound effect from treatment ... : Chronic infections
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Sideroblastic anemia ... Macroangiopathic, Infections ... aciduria, Drugs (e.g ... Differential #Diagnosis #hematology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
invasive fungal infection ... (IFI) in hematologic ... formulations (e.g ... surfaces - Infections ... non-neutropenic pts, SOT
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Chronic Disease (e.g ... Inflammation, Chronic Infection ... Algorithm #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic Anemia ... (AIHA) Treatment ... Steroids - 1-2 mg/kg ... Polyclonal: - Infection ... #management #hematology
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