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diagnosis management differential hivaids opportunistic pharmacology algorithm causes idsa oncology rheumatology syndrome hemeonc thrombocytopenia chronic dermatology disease leukemia workup aplastic
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelofibrosis Infectious ... effect following treatment ... Iron deficiency anemia ... #Thrombocytosis
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - ... Reactive: • Anemia ... deficiency) • Infection ... Sepsis • Non-infectious ... causes #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... ): • Acute infection ... malignancies • Anemia ... inflammatory disorders (e.g ... Diagnosis #Causes #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... → Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... : Chronic infections
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Diagnosis Algorithm Infectious ... • Thrombus (e.g ... Myeloproliferative disorders (eg ... vera, essential thrombocytosis ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g ... . cancer, infection ... Marrow suppression (e.g ... G6PD deficiency), Infections ... Production #Index #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... : • Recurrent infections ... Treatment: • Consider ... diagnosis #management #treatment ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... differential #diagnosis #hematology ... #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Sideroblastic anemia ... Macroangiopathic, Infections ... aciduria, Drugs (e.g ... Differential #Diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Chronic Disease (e.g ... Inflammation, Chronic Infection ... Algorithm #Causes #Hematology
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