1657 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
blood loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Hypo-Mg2+ • Vitamin deficiency ... • Seizures • Hemolysis ... • Vitamin D deficiency ... hyperparathyroidism Treatment
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... • Severe B12 deficiency ... • Mechanical hemolysis ... macroangiopathic hemolytic
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Scurvy (Vitamin C Deficiency ... : • Vitamin C deficiency ... contribute to nonimmune hemolysis ... vasculitis Treatment
Hemolytic Anemia - Hemolysis Diagnostic Workup

Infographic by: Howard Ong

#Hemolysis #Hemolytic #Anemia #Algorithm #MAHA #TTP #Diagnosis #Workup
Hemolytic Anemia ... - Hemolysis Diagnostic ... Howard Ong #Hemolysis ... #Hemolytic #Anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Defects • G6PD deficiency ... • PK deficiency ... Intravascular - Hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... purpura (TTP), Hemolytic ... G6PD deficiency)
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... Immune-mediated Hemolysis ... • Autoimmune Hemolytic ... • Alloimmune Hemolytic
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Cold Autoimmune Hemolytic ... Warm Autoimmune Hemolytic ... Spherocytes • Treatment ... Cold Autoimmune Hemolytic ... • Treatment: Warm
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... Immune mediated hemolysis ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic