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diagnosis hematology management lupus algorithm ana erythematosus systemic patterns workup antibody testing arthritis cardiology endocarditis joint pain pulmonary thrombocytopenia vasculitis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Thrombotic Microangiopathies In Systemic Lupus Erythematosus Dr. Laurent ARNAUD @Lupusreference #TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE ... #hematology #rheumatology ... #differential # ... diagnosis #causes
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic antibodies ... in drug-induced SLE ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... #Hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Kumfer @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Highly specific for SLE ... Association with both SLE ... Lupusreference #Antinuclear ... erythematosus #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Scl70 (in some cases ... ARUPLabs #ANA #Antinuclear ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... test, ANA (e.g., SLE ... anti-phospholipid antibodies ... Platelet #Disorders #Differential ... #Workup #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... Cytopenia: Common • Immunologic ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... - Differential ... • Anti-GBM antibodies ... (MPA) • SLE ... Proteinuria #Nephrology #Differential
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