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diagnosis hematology management chronic classification differential lymphocytic mds myelodysplastic syndrome abscess algorithm apml comparison differentiation disorders emergencies fungal hemophagocytic hlh
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... -> AML: Blast crises ... splenomegaly), night ... Fevers • Drenching night ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Drenching night ... microglobulin Treatment ... leukemia #CLL ... diagnosis #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... symptoms → fevers, night ... uw_IMresidency #CLL ... #oncology #hematology ... #hemeonc #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... transformation to acute leukemia ... Allogeneic stem cell ... only curative treatment ... #hematology #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Responsive to Treatment ... Treated Like Acute Leukemias ... very high mitotic rate ... Classification #pathophysiology ... #Hematology #Diagnosis
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
without other cause ... : 33% • Treatment ... CKD, CHF, high rate ... , and CXR with pulmonary ... : No • Treatment
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
• Most common cause ... Lung Abscess Pathophysiology ... degrees • Chills, night ... Lung #Abscess #pulmonary ... #differential #causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... • Induce blast cell ... Imaging: CXR- pulmonary ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Treat underlying cause ... Usually myeloid leukemias ... ± tocilizumab; call ... renal failure, pulmonary ... #HemeOnc #Diagnosis
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