49 results
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Volume (MCV) - Differential ... Hypersplenism • Secondary ... Normal RBCs • Acute ... Bleed • Hemolysis ... #Differential #
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... atypical HUS) - Drug-induced ... anemia" • HELLP ... #schistocytes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... delayed HTR • Drug-induced ... anemia • ... Acute HTR - Mechanical ... Algorithm #Causes #Hematology
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
Hyperuricemia - Differential ... Disorders • Acute ... (ALL) • Acute ... Leukemia (CML) - Hemolytic ... Anemia - Others
Drugs Implicated in Hemolytic Anemia
 • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... in Hemolytic Anemia ... • Hapten (Drug ... #medications #Hemolytic ... #Anemia #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... infection) - Drugs ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Orotic aciduria, Drugs ... #Diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA)

WARM AHA
- Primary - Idiopathics
- Secondary
Infectious
 • Viral- HIV, EBV, HCV, HEV
 •
Autoimmune Hemolytic ... Anemia (AIHA) ... polyangiitis Drug ... #Anemia #AIHA # ... Diagnosis #Differential
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Diagnosis Secondary ... Thrombocytosis): • Acute ... malignancies • Anemia ... iron deficiency, hemolysis ... #secondary
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
suppression (e.g. drugs ... Index > 3: • Acute ... Microangiopathic hemolytic ... Production #Index #hematology ... #anemia #differential