803 results
Bone resorption and the relationship between osteoblasts and osteoclasts.  
RANK is expressed on the osteoclasts,
Bone resorption ... relationship between osteoblasts ... marrow cells and osteoblasts ... RANK stimulates osteoclast ... projections from an osteoclast
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... forms bony callus ... mos - yrs) • Osteoclast-osteoblast ... coupled bone remodeling ... from GI tract, bone
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... metastasized to the bone ... • Metastatic bone ... cells activate osteoblasts
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... -> Reduced Bone ... Formation, Increased Bone
Pharmacologic Options for Hypercalcemia Associated with Cancer
Rehydration with NS followed by loop diuretics
 • IV normal
acid - Inhibits osteoclast ... activity; decreases bone ... RANKL to decrease osteoclast ... Calcitonin - Inhibits bone ... nitrate - Inhibits osteoclast
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... IGFIR activates osteoblasts
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Osteoporosis - Increased osteoclast ... activity and bone ... resorption - Bone
Humerus Bony Anatomy - Anterior and Posterior Views

By @rev.med

#Humerus #Bony #Anatomy #MSK #Bone
Humerus Bony Anatomy ... rev.med #Humerus #Bony ... #Anatomy #MSK #Bone
Diagram of different types of bone tumors that can occur around the knee on XRay -
different types of bone ... Simple/unicameral bone ... • Aneurysmal bone ... docskalski #Knee #Bone ... Tumors #Diagnosis #Bony
Bone Tumor Location within the Skeleton

Epiphysis: 
Only a few lesions are located in the epiphysis, so
Bone Tumor Location ... degenerative subchondral bone ... #Bone #Tumor #Location ... #Differential #Bony