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Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... Parathyroid gland ... adenoma • Parathyroid ... disease of bone Malignancy ... Hypercalcemia #Causes
Mechanism of malignancy-associated hypercalcemia. Abbreviations: 1,25(OH)2D, 1,25-dihydroxyvitamin D; NHL, non-Hodgkin lymphoma; PTH, parathyroid hormone; PTHrP, PTH-related
Mechanism of malignancy-associated ... lymphoma; PTH, parathyroid ... Hypercalcemia #Malignancy
Workup of Hypercalcemia - Differential Diagnosis Algorithm High or Normal PTH: • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Hyperparathyroidism: Parathyroid ... adenoma, Parathyroid ... hyperplasia, Parathyroid ... • High PTHrP: Malignancy ... nephrology #PTH #parathyroid
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... • Burns Non malignant ... effect following treatment ... Non-hematologic malignancy ... Diagnosis #Algorithm #Causes
Dyspnea - Considerations with Malignancy Directly Malignancy Related: - Lymphangitic spread to lung - Malignant pleural effusion
Considerations with Malignancy ... Directly Malignancy ... spread to lung - Malignant ... pleural effusion - Malignant ... metastases Treatment
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
Hydronephrosis • Malignant ... Stricture • Malignancy ... Hematuria: • Malignancy ... Urolithiasis • Malignancy ... Differential #Diagnosis #causes
Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
Hypercalcemia of Malignancy ... PTH-mediated • Parathyroid ... Hypercalcemia #Malignancy
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... Parathyroid hormone–dependent ... hyperparathyroidism) Parathyroid ... Neoplasms - Parathyroid ... Hypercalcemia #Causes
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 Hyperthermia Syndromes Comparison Serotonin Syndrome - NMS - Malignant Hyperthermia - Malignant Catatonia Cause - Onset - Vitals
Syndrome - NMS - Malignant ... Hyperthermia - Malignant ... Catatonia Cause ... Mental Status - Treatment
Radial Fracture Due to Parathyroid Carcinoma- ...A plain radiograph of the left arm showed a diaphyseal
Fracture Due to Parathyroid ... with an intact parathyroid ... found to have parathyroid ... which is a rare cause ... the patient’s parathyroid
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