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diagnosis differential lupus management erythematosus systemic dermatology symptoms antibodies autoantibodies cutaneous diseases druginduced syndrome table thrombocytopenia algorithm ana anca antibody
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vasculitis Involving ... Secondary: CTD: SLE ... , infections, drug ... #skin #dermatology ... #rheumatology #
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
methotrexate) • Drugs ... Autoimmune • ITP • SLE ... anti-HLA antibodies Drugs ... HUS • DIC • Vasculitis ... Algorithm #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Secondary Causes: - Drug ... Splenomegaly - CTD (SLE ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology #
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
angiitis (40%) • Drug-induced ... vasculitis (20% ... disease (10%) : SLE ... #dermpath #dermatology ... #semiology #signs
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-histone - Drug-induced ... SLE Anti-Jo-1 - ... disease c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... diagnosis #table #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Butterfly rash, Vasculitis ... Thrombocytopenia #Lupus #SLE ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• Drug Associated ... purpura: strong sign ... polyarteritis, drug-induced ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... Erythematosus (SLE ... #comparison #table ... #rheumatology #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-histone (in drug-induced ... SLE) • Systemic ... ANCA-Associated Vasculitis ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
involvement 3% SLE-Related ... Lupus Mimickers: Drug-induced ... Lupusreference #SLE ... autoantibodies #signs ... #differential #rheumatology
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