27 results
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Immunosuppressant Drugs ... -1, IL-2 Muromonab-CD3 ... Immunosuppressant #Drugs ... #Pharmacology # ... Pathophysiology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... , 4:1 to 1:1 F:M ... Prognosis: Usually mild ... Age 20-40, F:M 9:1 ... comparison #table #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... glycoprotein I (ß2GP), Lupus ... Myositis: Anti-JO-1, ... RNA Polymerase Ill
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
this should be 1° ... Arthritis, Systemic Lupus ... Radiaition • Drugs ... Chronic Radiation Pneumonitis ... Lung #Diseases #ILD
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... - Anti-PCNA 1- ... Mimickers: Drug-induced ... lupus, Cutaneous ... #differential #rheumatology
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... retroviruses), Drugs ... Interferon-a, IL ... #Lupus #Erythematosus ... #SLE #Pathophysiology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
pneumonitis • ... extremities Drug ... • ANA titers > 1: ... Ro/La, anti-Jo-1, ... • Antihistone: Drug
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Drug Induced Systemic ... Lupus Erythematosus ... SLE #Systemic #Lupus ... #pharmacology # ... differential #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic lupus ... Farr assay) and lupus ... SLE (60-70%) & drug-induced ... syndromes Anti-PCNA 1- ... erythematosus #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... erythematosus 1. ... Anti-histone (in drug-induced ... dermatomyositis 1. ... antibodies #diagnosis #rheumatology