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Pathophysiology, Signs and Symptoms of Hemolytic Anemia

#Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Pathophysiology, ... Signs and Symptoms ... Hemolytic Anemia #Pathophysiology ... Hemolytic #Anemia #hematology ... diagnosis #signs #symptoms
Rheumatoid Arthritis Summary
MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Pulmonary Disease and ILD ... RA #diagnosis #rheumatology ... #signs #symptoms
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... : ARDS Berlin Criteria ... ARDS to explain symptoms ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
activity, ↑ soluble IL ... the following 8 criteria ... activity • ↑ soluble IL ... Lymphohistiocytosis #diagnosis #hematology ... #criteria
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria ... pericarditis • Hematologic ... nephritis, Class Ill ... Classification #Criteria ... Erythematosus #diagnosis #rheumatology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
to be normal. 1: ... 1 Mix of Patient's ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Myositis: Anti-JO-1, ... RNA Polymerase Ill ... Autoantibodies #Rheumatology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... Classic triad of ILD ... Myositis #diagnosis #rheumatology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
the chest/trunk Symptoms ... 5 of the below criteria ... should be major: 1. ... Minor criteria include ... AOSD #diagnosis #rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... (MDS) Most met criteria ... for 1) hematologic ... Autoinflammatory #Somatic #rheumatology