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diagnosis differential hemolytic management algorithm causes oncology rbc atlas clinical extravascular intravascular microscopy morphology agglutinin analysis anemias blood bloodcell bodies
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Hemolytic Anemias ... (AIHAs) • Alloimmune ... Hemolytic Anemias ... Diagnosis #Algorithm #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... MatthewHoMD #Autoimmune ... #Hemolytic #Anemia ... Diagnosis #Table #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... (AIHA) "Warm" ( ... Hemoglobinopathies (e.g. sickle ... differential #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
• Alloimmune ... Thalassemia • Sickle ... cell • Unstable ... anemia • ... Algorithm #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... #Autoimmune #Hemolytic ... #Anemia #Pathophysiology ... #diagnosis #hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Microspherocytes: Autoimmune ... hemolytic anemia ... Sickled red cells ... : Sickle cell disease ... Smear #Analysis #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... #Autoimmune #Hemolytic ... #Anemia #AIHA # ... Treatment #management #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Hemoglobin Defects: Sickle ... cell anemia, Thalassemias ... Differential #Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
: Autoimmune, Microangiopathic ... hemolytic anemia ... defects (e.g. sickle ... cell anemia, G6PD ... Production #Index #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... cells - Consider sickle ... cell disease (diverse ... elliptocytosis, autoimmune ... Algorithm #workup #hematology
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