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differential lupus sle workup systemic treatment hemolytic algorithm syndrome oncology signs symptoms table causes classification dermatology hemolysis pancytopenia summary aiha
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... lupus erythematosus ... #Hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis ... Cold Agglutinin Disease ... #Table #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... Warm #Antibody #Autoimmune ... #diagnosis #management ... #treatment #rheumatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
spherocytosis, Autoimmune ... hemolytic anemia ... Agglutinate: Cold autoimmune ... #differential #diagnosis ... #hematology #microscopy
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
DAT Results in Autoimmune ... Cold agglutinin disease ... #antiglobulin #test ... #Hemolysis #hematology ... #diagnosis
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Initial screening test ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... - Extrinsic: Autoimmune ... Non-megaloblastic: Liver disease ... #Differential #Diagnosis ... #hematology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Systemic Lupus Erythematosus ... NEUROLOGIC - HEMOLYTIC ANEMIA ... Direct Coombs’ test ... #Diagnosis #Rheumatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Membrane): - Autoimmune ... Defects: Sickle cell anemia ... Laboratory Tests ... #hematology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Chain deposition disease ... Atypical HUS, autoimmune ... Systemic Lupus Erythematosus ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
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