16 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Step 1: Is the PT ... Heparin, or Direct Thrombin ... Prolonging the PT ... or APTT? ... #prolonged #diagnosis
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Tests - Prolonged PT ... - Prolonged aPTT ... and Prolonged PT ... #Laboratory #Hematology ... #Diagnosis #Workup
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Coagulation Tests PT ... / INR, aPTT, Anti-Xa ... Clotting Time, Thrombin ... Anticoagulation #Testing #Diagnosis ... #Laboratory #Effects
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Prothrombin Time (PT ... Prothrombin Time (PT ... thematttsai #PT ... Thromboplastin #laboratory ... #hematology #diagnosis
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... typically prolong PT ... drugs e.g. direct thrombin ... #Causes #diagnosis
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
GI. uterine) Laboratory ... 2B) • Normal PT ... INR • Normal aPTT ... VonWillebrand #Disease #Diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... for a Prolonged PT ... PT and the aPTT ... drugs (e.g. direct thrombin ... #Causes #diagnosis
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
- Differential Diagnosis ... 12-13 g/dL, • ANC ... iron studies, PT ... /aPTT Differential ... Diagnosis: •
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... • Increased thrombin ... venipuncture sites Laboratory ... INR < 2.3 - APTT ... #Coagulation #diagnosis