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diagnosis rheumatology management classification differential hematology summary symptoms activation ana anca anesthesia anesthesiology antibody antineutrophil antinuclear antinxp2 antinxp2dm arthritis autoantibodies
Renal involvement in Systemic Lupus Erythematosus (SLE) Dr. Laurent ARNAUD @Lupusreference #Renal #lupus #nephritis #SLE #Systemic #Erythematosus #SLE
in Systemic Lupus ... Erythematosus ( ... #SLE #Systemic ... #Erythematosus # ... #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... life-threatening • Treatment ... #lupus #Systemic ... #Erythematosus
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Auto-Antibodies ... #Systemic #Lupus ... #Erythematosus ... autoantibodies #signs
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... /systemic sclerosis ... severe disease Treatment ... #Lupus #Erythematosus
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Lupus Erythematosus ... hemolysis • Renal ... Highly specific antibodies ... Classification #Criteria #SLE ... #Systemic #Lupus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Abdominal pain (20%) Renal ... #SLE #systemic ... #erythematosus # ... signs #symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lupus erythematosus ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies ... #Systemic #Lupus
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months to years) Systemic ... Lupus Erythematosus ... • Immunologic Workup ... life-threatening • Treatment
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... erythematosus ... in drug-induced SLE ... ) • Systemic sclerosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... lupus erythematosus ... [SLE], AOSD) • ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
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