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diagnosis differential rheumatology management symptoms erythematosus algorithm classification joint oncology rash clinical neurology secondary syndrome arthritis blood bruising photo skin
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Butterfly rash, Vasculitis ... (20%) Renal disease ... #SLE #systemic ... erythematosus #signs
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Malar rash • SLE ... Hypersensitivity vasculitis ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #joint #pain #skin
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Polyarteritis Nodosa (PAN ... vasculitis (rare ... Arthritis (RA), Systemic ... lupus erythematosus ... (SLE), Sarcoidosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... (SLE), Sjogren's ... (SLE), Systemic ... : Lupus (SLE), Systemic ... #patterns #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... lupus erythematosus ... in drug-induced SLE ... Vasculitis: • ... vasculitis - MPO
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... Positive in 60-80% of cases ... Evolution: Chronic disease ... #lupus #Systemic
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Antinuclear Antibody (ANA ... Arthritis R Renal ... Disease (Nephritis ... #IMDAMNSHARP #sle ... #systemic #lupus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... Others: • Lupus ... purpura: strong sign ... LFT • ESR • ANA ... , and SLE) • Urinalysis
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... & renal involvement ... #Lupus #Erythematosus ... diagnosis #rheumatology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... Connective tissue disease ... (10%) : SLE +++ ... #dermpath #dermatology ... #semiology #signs
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