38 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
process whereas secondary ... diseases • In secondary ... (PBC), or with systemic ... lupus erythematosus ... (SLE) Signs /
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Demyelinating syndromes ... Abdominal pain (20%) Renal ... #SLE #systemic ... erythematosus #signs
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Demyelinating Syndrome ... APS), Secondary ... #rheumatology #
Mucous Membrane Disorder - Differential Diagnosis Algorithm
Erosions/Ulcers/Blisters
 - Primary Dermatologic Diseases
     •
Ulcers/Blisters - Primary ... Dermatologic Diseases ... necrolysis - Systemic ... lupus erythematosus ... MucousMembranes #dermatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... block • Sjogren syndrome ... #Lupus #Erythematosus ... diagnosis #rheumatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Diagnosis Algorithm - Systemic ... BUN: • Chronic renal ... Myelodisplastic syndrome ... #secondary #systemic ... #generalized #dermatology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
inhibitors, hepatorenal syndrome ... Glomerulonephritides (GN) • Primary ... nephropathy • Secondary ... GNs: Due to systemic ... Post-infectious GN, Lupus
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Syndrome (SS), ... (SLE), Systemic ... (SLE), Systemic ... Arthritis, Sjögren Syndrome ... Autoimmune Hepatitis, Primary
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... Abnormality • SLE ... discoloration) • Chronic renal ... • Nephrotic syndrome ... #Secondary #dermatology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
skin thickening Signs ... Hepatic: PBC (primary ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup