11 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
(PBC), or with systemic ... arthritis (RA) or systemic ... lupus erythematosus ... (SLE) Signs / ... #Diagnosis #Signs
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... loss (50%) Eye: Sjögrens ... Demyelinating syndromes ... #SLE #systemic ... erythematosus #signs
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... and Sjogren Anti-SSB ... Associated with Sjogren ... overlap syndromes ... #rheumatology #table
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SSc: systemic sclerosis ... PSS: Sjogren syndrome ... rheumatoid arthritis SLE ... : systemic lupus ... Differential #Comparison #Table
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... (SLE): ANA (anti-nuclear ... Anticoagulant (LAC) • Sjogren ... • Scleroderma (Systemic ... #associations #table
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
Arthritis • Systemic ... Lupus Erythematosus ... • Sjögren's ( ... Sicca) Syndrome ... Inflammatory #JointPain #MSK
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Female • Peaks 3rd ... dermatomyositis, Sjogren ... Neuropsychiatric systemic ... #Systemic #Lupus
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
associated with systemic ... Musculoskeletal system ... Episcleritis Signs ... - Lupus - Leukemia ... #diagnosis #dermatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... enlargement Sjogren's ... phenomenon (16%) MSK ... Biologic: 2nd or 3rd
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune system ... non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... ’s CLL Scoring system ... AIHA • Pure red