10 results
Antiphospholipid Syndrome (APS)
APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Syndrome (APS) ... antibodies (aPL ... or small-vessel thrombosis ... 1 of the three aPLs ... #Syndrome #APS
2019 EULAR recommendations for thrombosis in (Antiphospholipid Syndrome) APS
Venous Thrombosis - Arterial Thrombosis
INR Target
Duration
Recurrence

Dr. Laurent ARNAUD
in (Antiphospholipid ... Syndrome) APS ... #Antiphospholipid ... #Syndrome #APS ... #rheumatology #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Differential Diagnosis ... Hyperviscosity, TTP, APLS ... • Nephrotic Syndrome ... Malignancy - Antiphospholipid ... antibodies (APLS
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... hemolysis: • Thrombotic ... hemolytic-uremic syndrome ... • Catastrophic APLS ... #hematology #hemolysis
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
actor for arterial thrombosis ... - No other workup ... Hypercoagulable #Workup ... #hematology #diagnosis ... #algorithm #hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... /HUS indicates thrombotic ... hemolytic uremic syndrome ... thrombocytopenia, Hematology ... 2012, p 193 #Diagnosis
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
Antiphospholipid ... Syndrome (APLS) ... Hypercoagulable Workup ... #Antiphospholipid ... #diagnosis #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... vasculopathy, thrombosis ... permeability Diagnosis ... (for secondary APS ... Erythematosus #SLE #CNS #neurology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
necrosis) - Thrombosis ... (Thrombotic vasculopathy ... Cryofibrinogenemia Diagnosis ... HUS and HIT • Antiphospholipid ... syndrome • Warfarin-induced
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
- Differential Diagnosis ... Supply: - AVM - Antiphospholipid ... Spinal artery thrombosis ... MCTD, Sjogren syndrome ... #neurology #differential