9 results
Antiphospholipid Syndrome (APS)
APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Syndrome (APS) ... unknown Diagnosis of APS ... or small-vessel thrombosis ... recommended in APS ... #Syndrome #APS
Low-dose aspirin and low-molecular-weight heparin in lupus and Antiphospholipid Syndrome (APS) pregnancy

• No previous history of
Syndrome (APS) ... BUT high-risk aPL ... APS (arterial or ... history of obstetric APS ... #Syndrome #APS
2019 EULAR recommendations for thrombosis in (Antiphospholipid Syndrome) APS
Venous Thrombosis - Arterial Thrombosis
INR Target
Duration
Recurrence

Dr. Laurent ARNAUD
in (Antiphospholipid ... Syndrome) APS ... #Antiphospholipid ... #Syndrome #APS ... #rheumatology #hematology
2019 EULAR Recommendations - Obstetrics Management in (Antiphospholipid Syndrome) APS
Previous Thrombosis?
Previous Pregnancy Complications?

Dr. Laurent ARNAUD @Lupusreference

#obstetrics
Management in (Antiphospholipid ... Syndrome) APS ... Previous Thrombosis ... #obstetrics #Antiphospholipid ... #Syndrome #APS
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
imaging → Test for APS ... actor for arterial thrombosis ... - No other workup ... Inherited and APS ... Inherited and APS
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Hyperviscosity, TTP, APLS ... • Nephrotic Syndrome ... Malignancy - Antiphospholipid ... antibodies (APLS ... pathophysiology #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
hemolysis: • Thrombotic ... hemolytic-uremic syndrome ... - Drug-induced thrombotic ... anemia" • HELLP syndrome ... • Catastrophic APLS
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
Antiphospholipid ... Syndrome (APLS) ... Hypercoagulable Workup ... ARUPConsult @ARUPLabs #APLS ... #Antiphospholipid
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... vasculopathy, thrombosis ... (for secondary APS ... Erythematosus #SLE #CNS #neurology