51 results
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
vasculitis - Diagnosis ... vasculitis Clinical ... neuropathy Treatment ... with refractory disease ... #Vasculitis #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • Autoimmune diseases ... : - 10% SLE or ... Labs/Diagnosis: ... classification #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... ) - Viral infections ... vasculitis/HSP • Cryoglobulinemia ... Associated - SLE ... #hematology #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : SLE+++, Adult-onset ... Still disease, ... #summary #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... related vasculitis, infections ... Urticarial/LCV) - Cryoglobulinemic ... Vasculitis: • Behcet Disease ... #dermatology #rheumatology
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... (10%) : SLE +++ ... vasculitis (3%) • Infections ... signs #lesions #diagnosis ... #clinical #manifestations
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... Differential Diaqnoses ... : • Infectious ... #diagnosis #management ... #treatment #rheumatology
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
in 24h Airway disease ... Parenchyma: • Infection ... Kaposi's sarcoma • Rheumatologic ... > EGPA, MPA), Cryoglobulinemia ... Goodpasture's, SLE
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... 40, F:M 9:1 • Clinical ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... is clinically suspected ... erythematosus #diagnosis ... #rheumatology # ... table #ANA