12 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... C3d • Blood smear ... #Autoimmune #Hemolytic ... #Anemia #diagnosis
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential Diagnosis ... Abnormal peripheral smear ... : • Autoimmune ... (AIHAs) • Alloimmune ... #Differential #Diagnosis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... or negative - Smear ... C3 positive - Smear ... #Hemolytic #Anemia ... Pathophysiology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... - Differential Diagnosis ... Peripheral blood smear ... idiopathic, malignancy, autoimmune ... #Differential #Diagnosis
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... Inflammatory and Autoimmune ... hemoglobinuria • Antibody-mediated ... hemolysis Nutritional ... #Differential #Diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Membrane): - Autoimmune ... Peripheral Blood Smear ... #Differential #Diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... Diagnosis: • hemolytic ... • Compensated hemolysis ... IgM) • Blood smear ... CLL (older) • Autoimmune
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Thrombocytopenia, Autoimmune ... hemolysis • Renal ... Antiphospholipid antibody ... , Anti-Sm antibody ... Erythematosus #diagnosis
Atypical HUS - Hemolytic Uremic Syndrome
Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Atypical HUS - Hemolytic ... minus diarrhea (autoimmune ... on peripheral smear ... Atypical #HUS #aHUS #Hemolytic ... Uremic #Syndrome #diagnosis
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
LDH - Assess for hemolysis ... antigen, hepatitis C antibody ... ANA - Screen for autoimmune ... ), and certain autoimmune ... testing #workup #diagnosis