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Renal Actions of Diuretics

#Diuretics #Sites #Action #Nephron #Pharmacology #Nephrology
Renal Actions of ... Sites #Action #Nephron ... #Pharmacology # ... Nephrology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Non-anion Gap Metabolic ... Generalized distal nephron ... ketosis with ketone excretion ... aniongap #NonGap #Metabolic ... #nephrology
Unmeasured Anions Associated with an Elevated Anion Gap and Metabolic Acidosis

#Unmeasured #Anions #Gap #Metabolic #Acidosis #Diagnosis
Anion Gap and Metabolic ... #Anions #Gap #Metabolic ... Acidosis #Diagnosis #Nephrology ... #Table #Differential ... #Causes
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... tubal acidosis and metabolic ... antidiuretic hormone secretion ... Diagnosis #Algorithm #Causes ... #nephrology
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... organic acids and bases ... vasopressin control #Nephron ... Pathophysiology #Tubules #Table ... #Pharmacology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Excretion Carbonic ... resistance • Metabolic ... Kidney stones caused ... #Nephrology #Pharmacology ... #Medications #Table
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Causes of Hypomagnesemia ... (steatorrhea) Renal ... Tubulointerstitial renal ... Hypomagnesemia #Causes ... medications #drugs #pharmacology
Causes of Hypomagnesemia
 • Redistribution: IV glucose, Correction of diabetic ketoacidosis, IV hyperalimentation, Refeeding after starvation,
Causes of Hypomagnesemia ... steatorrhea) • Renal ... Tubulointerstitial renal ... Hypomagnesemia #Causes ... differential #diagnosis #nephrology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Acquired - Primary renal ... Obstructive uropathy, Metabolic ... causes (e.g., hypokalemia ... Classification #Types #Nephrology
Adrenoceptor Actions
α1
 • Vascular smooth muscle - Contraction
 • Genitourinary smooth muscle - Contraction
 • Intestinal
ß-cells - ↓ Insulin secretion ... conduction velocity • Renal ... cells - ↑ Renin secretion ... receptors #actions #pharmacology ... pathophysiology #comparison #table