Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 β€’ AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... Injury? ... Transaminitis #diagnosis #differential ... #hepatology
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... #DrugInduced #Liver ... #Injury #Pathophysiology ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury β†’ liver test abnormalities without evidence of liver
Injury - Differential ... Injury β†’ liver ... Injury Differential ... #Injury #Differential ... #Diagnosis #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 β€’ NAFLD
 β€’ Cirrhosis
 β€’
Elevated Liver Function ... Tests (LFTs) - Differential ... injury) β€’ Ischemic ... #Tests #LFTs #Differential ... #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 β€’ Infectious: Hepatitis C, A,
Causes of Acute Liver ... Injury - Differential ... Hepatocellular - Liver ... #Injury #Differential ... Acute #algorithm #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 β€’ Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... or symptoms of liver ... #differential # ... gastroenterology #hepatology
Hepatopulmonary Syndrome (HPS) 

HPS-differential diagnosis:
1. Pulmonary vasculature
2. Diseases of the lung parenchyma
3. Pleura and diaphragm

HPS-diagnosis:
1. Patients
(HPS) HPS-differential ... Pulmonary vasculature ... Patients with liver ... Syndrome #HPS #hepatology ... #pulmonary #diagnosis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... Injury Transaminase ... #Patterns #Liver ... #Injury #hepatology ... transaminitis #differential
Liver Mass Differential Diagnosis
Solid:
 β€’ Benign: Hepatic Hemangioma, Focal nodular hyperplasia, Hepatocellular adenoma, Regenerative nodules
 β€’
Liver Mass Differential ... Cystadenoma, Polycystic liver ... Echinococcus #Liver ... #Mass #Differential ... #Diagnosis #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... Hepatocellular injury ... 2: Cholestatic injury ... Transaminitis #diagnosis #hepatology