Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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diagnosis management anemia dermatology clinical differential hemophagocytic hlh lupus lymphohistiocytosis rash adultonset blood causes comparison product reactions skin sle stills
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
cold agglutin disease ... Mycoplasma pneumoniae infection ... Drugs (Beta lactam antibiotics ... spherocytosis) • Infections ... differential #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Anemia (AIHA) Treatment ... esp if severe disease ... Polyclonal: - Infection ... #Anemia #AIHA #Treatment ... #management #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell disease ... , Hemoglobin H disease ... inclusions - If infection ... Algorithm #workup #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Causes: • Liver disease ... drug induced • Infections ... udaygulati #Hemolytic ... classification #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Chronic kidney disease ... (e.g. cancer, infection ... Microangiopathic hemolytic ... G6PD deficiency), Infections ... Production #Index #hematology
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group < 5%
Non-HCV infectious ... neuropathy Treatment ... Specific anti-infectious ... with refractory disease ... Cryoglobulinemia #Vasculitis #Rheumatology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... megaloblastic anemia Treatment ... (transfusions, antibiotics ... diagnosis #management #treatment ... #hematology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Diaqnoses: • Infectious ... autoinflammatory diseases ... diagnosis #management #treatment ... #rheumatology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
malnutrition, Antibiotics ... Malabsorption (e.g. celiac disease ... Advanced Liver Disease ... Deficiencies #Summary #table ... comparison #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
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