The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Major Depressive ... included in DSM 5 criteria ... MajorDepressiveDisorder #Depression ... MoodDisorders #Diagnosis ... Pathophysiology #Signs
Borderline Personality Disorder: Pathogenesis and Clinical Findings
Behavioral Traits:
 • Unstable Relationships - Alternating extremes of idealization
Borderline Personality ... impairment #BPD #Borderline ... PersonalityDisorder #Diagnosis ... #Psychiatry #Criteria ... #Signs #Symptoms
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
inflammatory cytokine expression ... yrs old; F>M Signs ... /Symptoms: - Fever ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Chronic Exertional Compartment Syndrome (CECS)
 • Diagnosis Of CECS requires patient to undergo the same exertional
Syndrome (CECS) • Diagnosis ... • Diagnostic ... criteria for CECS ... ChronicExertional #CompartmentSyndrome ... #signs #symptoms
Antisocial Personality Disorder (ASPD): Pathogenesis and Clinical Findings
Work & lnterpersonal:
 • Home Life Troubles - Conflict
Antisocial Personality ... disorder #ASPD #Antisocial ... PersonalityDisorder #Diagnosis ... #Psychiatry #Criteria ... #Signs #Symptoms
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... cause the Positive Symptoms ... Diminished emotional expression ... pathophysiology #diagnosis ... #symptoms #signs
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Upregulate gene expression ... pathophysiology #signs ... #symptoms #diagnosis
Xeropthalmia: Pathogenesis and Ocular Manifestations

Decr Visual pigment -> Keratinization, thickening & non-wetting of the conjunctiva
& Decr surface expression ... ophthalmology #diagnosis ... #signs #symptoms
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
findings - For diagnosis ... to 25 for new diagnosis ... Pathophysiology #diagnosis ... #symptoms #signs ... #psychiatry #criteria
Seasonal Affective Disorder: Pathogenesis and clinical findings

Symptoms (included in the DSM-V) - Two Major Depressive episodes
clinical findings Symptoms ... season at work) Symptoms ... MoodDisorders #Diagnosis ... Pathophysiology #Signs ... #Symptoms #Psychiatry